Section: Partnerships and Cooperations

National Initiatives

• Project acronym: HM-TC

• Project title: Model of the hippocampo-cortical connectivity in “temporal consciousness” in normal and pathological memory derived from multimodal anatomical and functional brain imaging (aMRI, DT-MRI, MEG, fMRI)

• Duration: Nov 2009- Nov 2014

• Amount: 2M€

• Coordinator: Olivier Colliot (ARAMIS) and Gianfranco Dalla Barba

• Other partners: CENIR, ENS Cachan, Neurospin, Grenoble Institut des Neurosciences

• Abstract: The aim of this project is to evaluate the role of the medial temporal lobe and its connections with various cortical regions in temporal consciousness related tasks and to derive a neuro-computational model of memory processing from multimodal imaging data. Temporal consciousness is defined as the ability to specify one’s own time-location with respect to past, present and future, and is thus a more general framework than episodic memory. Based on an original cognitive model and relying on memory dysfunctions called confabulations, different groups of participants (controls, patients with Alzheimer’s disease, patients with several memory disorders) will be evaluated through behavioural tests, MEG, anatomical, functional and diffusion-tensor MRI. New signal and image processing methods will be developed for all these modalities, in order to describe in a more robust and precise way both the anatomy and the function of the medial temporal lobe. First, using in vivo ultra high field MRI acquisitions (7 Tesla), we will build a precise anatomical atlas of the hippocampus and its inner structure. This model will allow designing efficient MEG source reconstruction in these regions, and new methods to analyse anatomical and functional connectivity. Using the most recent mathematical achievements in the theory of diffeomorphic deformations, we will propose new registration and morphometry methods in order to analyze very precisely the structural alterations of the medial temporal lobe. These new methods will be applied to the neuroimaging data acquired for the project in order to analyse extensively the relationships between memory disorders and structural and functional brain alterations revealed by neuroimaging.

• Project acronym: IHU-A-ICM

• Project title: Institute of Translational Neuroscience

• Founded in 2011

• General Director: Bertrand Fontaine

• The IHU-A-ICM program was selected, in 2011, in a highly competitive national call for projects. A 10-year, 55M€ program, has been implemented by a recently created foundation for scientific cooperation. Based on the clinical and scientific strenghts of the ICM and the hospital Department of Nervous System Diseases, it mainly supports neuroscience research, but is also invested in improving care and teaching. ARAMIS is strongly involved in the IHU-A-ICM project, in particular in WP6 (neuroimaging and electrophysiology), WP7 (biostatistics), WP2 (Alzheimer) and WP5 (epilepsy). We have started collaborations with the new bioinformatics/biostatistics platform (IHU WP7, head: Ivan Moszer), in particular through a joint project on the integration of imaging and genomics data.

• Project acronym: CATI

• Project title: Centre d'Acquisition et de Traitement des Images

• Founded in 2011

• Amount: 9M€

• Coordinator: Jean-François Mangin

• Other partners: Neurospin, CENIR, Inserm U678, IM2A

• Abstract: The CATI project (funded by the National Alzheimer Plan for 9M€, 2.1M€ for ARAMIS) aims at creating a national platform for multicenter neuroimaging studies. CATI aims to be a national resource for the scientific, medical and industrial research community and will provide a wide range of services: access to a national acquisition network, standardization of acquisitions, image quality control, image analysis, databasing/archiving, meta-analyses. Through CATI, our team coordinates a large network composed of over 30 image acquisition centers. CATI already supports over 15 multicenter projects including the national cohort MEMENTO (2300 subjects). CATI is integrated with France Life Imaging (PI: F. Lethimonnier) and the Neugrid for you (N4U, PI: G. Frisoni) network.

• Etude des interactions cortex-respiration. (Coordinators: P. Pouget and M. Chavez)

• Evaluating anesthetic depth using electroencephalographical recording in human and non-human primates. (Coordinators: P. Pouget and M. Chavez)

• PHRC (Programme Hospitalier de Recherche Clinique) PredictPGRN, co-funding by Alzheimer Plan, Caractérisation multimodale prospective de la démence frontotemporale dûe à des mutations du gène PGRN à un stade symptomatique et présymptomatique. (Coordinator : A. Brice)

• PHRC (Programme Hospitalier de Recherche Clinique) ImaBio3, co-funding by Roche (pharmaceutical industry), Rôle des réactions cellulaires sanguines, inflammatoires et immunitaires anti-amyloïde centrales et périphériques dans la maladie d’Alzheimer débutante. (Coordinator : M. Sarazin)

• PHRC (Programme Hospitalier de Recherche Clinique) CAPP, Caractérisation linguistique, anatomique/métabolique et biologique des différentes formes d'aphasie primaire progressive : vers le rationnel pour des essais pharmacologiques et des rééducations du langage ciblées. (Coordinator: M. Teichmann)